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David I Smith received his PhD in Biochemistry from the University of Wisconsin in 1978. He did post-doctoral research first at the Albert Einstein College of Medicine and then at the University of California, Irvine. His first faculty position was in the Department of Molecular Biology and Genetics at Wayne State University in Detroit. In 1996 he joined the Department of Laboratory Medicine and Pathology at the Mayo Clinic as a Professor. He is also the Chairman of the Technology Assessment Group for the Mayo Clinic Center for Individualized Medicine. The goal of this Group is to analyze new technologies for their potential impact on basic research and the clinical translation of these results. His laboratory studies the common fragile sites which are regions of profound genomic instability found in all individuals. His group is also studying the various ways that human papillomavirus is involved in the development of different cancers. His group uses different next-generation sequencing technologies to analyze where HPV has integrated into the human genome in these different cancers and the resulting genomic disruptions caused by these integrations.
Oropharyngeal cancer, Long noncoding RNA.